The Bauer Research Foundation (BRF) is dedicated to improving both human and animal health by educating the public about the critical role of one-carbon metabolism in supporting normal cellular function, healthy aging, and optimal neurological and cardiovascular performance.
Dr. Joseph A. Bauer, a biochemist with 27 years of experience in health and science, has carefully curated a list of supplements from Thorne that are backed by scientific evidence. These supplements aim to support overall health for both humans and animals.
What is One-Carbon Metabolism?
One-carbon metabolism refers to a network of biochemical reactions that are essential for nerve protection and function. For these reactions to occur properly, the body needs certain vitamins, known as cofactors, including:
5-methyltetrahydrofolate (5-MTHF) – the active form of folate
Methyl- and adenosyl-cobalamin (Me-Cbl, Ado-Cbl) – the active forms of vitamin B12
Research shows that as people age, levels of these critical cofactors tend to decline. A deficiency in these vitamins can disrupt one-carbon metabolism, leading to serious neurological problems that may contribute to the development of neurodegenerative diseases.
The Importance of Markers Like Homocysteine and Methylmalonic Acid
Markers like methylmalonic acid (MMA) and homocysteine (HCY) are often measured in patients with neurological conditions, depression, or dementia. Homocysteine is a particularly harmful molecule associated with unhealthy aging and several serious health conditions, including macular degeneration, cardiovascular disease, Parkinson’s, Alzheimer’s, and cancer.
Benefits of Supplementation
Studies have shown that supplementing with vitamin B12 and methylfolate (the active form of folate) can help restore balance to one-carbon metabolism and lower harmful homocysteine levels . This is especially helpful for individuals with vitamin B12 deficiencies or genetic mutations (such as MTHFR mutations) that affect how their bodies process these essential nutrients.
Supporting Cancer Patients with Nutraceuticals
In addition to supporting overall health, the BRF is dedicated to providing nutraceutical support for cancer patients. Research has shown that certain supplements not only have anti-cancer properties but can also help reduce the side effects of chemotherapy. The supplements recommended by Dr. Bauer include:
Vitamin D-5000
Omega-3 with CoQ10
R-lipoic acid
Carnityl® Acetyl-L-Carnitine
Phytoprofen (a blend of bromelain, ginger, and Boswellia)
Curcumin Phytosome: Meriva 500-SF
Boswellia Phytosome
Melatonin
Beta Alanine-SR
Review on methylation
Health Supplements for All Ages
Dr. Bauer recommends supplement bundles tailored to specific needs, including prenatal health, youth development, and healthy aging. It's never too early—or too late—to optimize your health. For more information, visit our Thorne online dispensary.
References:
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Ansari R, Mahta A, Mallack E, Luo JJ. Hyperhomocysteinemia and neurologic disorders: a review. J Clin Neurol. 2014.
Blasko I, Hinterberger M, Kemmler G, et al. Conversion from mild cognitive impairment to dementia. J Nutr Health Aging. 2012.
Coppede F, Tannorella P, Pezzini I, et al. Folate, homocysteine, vitamin B12, and polymorphisms of genes in one-carbon metabolism in Alzheimer's patients. Antioxid Redox Signal. 2012.
Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer’s. N Engl J Med. 2002.
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Hasan T, Arora R, Bansal AK, et al. Disturbed homocysteine metabolism is associated with cancer. Exp Mol Med. 2019.
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Kaye AD, Jeha GM, Pham AD, et al. Folic acid supplementation in patients with elevated homocysteine. Adv Ther. 2020.
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